UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

o

Rule 13d-1(b)

x

Rule 13d-1(c)

o

Rule 13d-1(d)

CUSIP No. 12738T100

1

Names of Reporting Persons.
Versant Affiliates Fund II-A, L.P.

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
61,124 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
61,124 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
61,124 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
0.12% (3)

12

Type of Reporting Person*
PN

(1)

This Schedule 13G is filed by Versant Affiliates Fund II-A, L.P., a Delaware limited partnership (“VAF II-A”), Versant Side Fund II, L.P., a Delaware limited partnership (“VSF II”), Versant Venture Capital II, L.P., a Delaware limited partnership (“VVC II”), Versant Side Fund IV, L.P., a Delaware limited partnership (“VSF IV”), Versant Venture Capital IV, L.P., a Delaware limited partnership (“VVC IV”), Versant Ventures II, LLC, a Delaware limited liability company (“VV II”), Versant Ventures IV, LLC, a Delaware limited liability company (“VV IV”), Brian G. Atwood (“BGA”), Samuel D. Colella (“SDC”), Ross A. Jaffe (“RAJ”), William J. Link (“WJL”), Donald B. Milder (“DBM”), Rebecca B. Robertson (“RBR”), Camille D. Samuels (“CDS”), Bradley J. Bolzon (“BJB”), Charles M. Warden (“CMW”), Barbara N. Lubash (“BNL”), Robin L. Praeger (“RLP”) and Kevin J. Wasserstein (“KJW” and together with VAF II-A, VSF II, VVC II, VSF IV, VVC IV, VV II, VV IV, BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW, BNL, KJW and RLP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)

VV II serves as the sole general partner of VAF II-A and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW and BNL are directors and/or members of VV II and share voting and dispositive power over the shares held by VAF II-A; however, they disclaim beneficial ownership of the shares held by VAF II-A except to the extent of their pecuniary interests therein. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009.

(3)

This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

CUSIP No. 12738T100

1

Names of Reporting Persons.
Versant Side Fund II, L.P.

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
28,787 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
28,787 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
28,787 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
0.06% (3)

12

Type of Reporting Person*
PN

(1)

This Schedule 13G is filed by Versant Affiliates Fund II-A, L.P., a Delaware limited partnership (“VAF II-A”), Versant Side Fund II, L.P., a Delaware limited partnership (“VSF II”), Versant Venture Capital II, L.P., a Delaware limited partnership (“VVC II”), Versant Side Fund IV, L.P., a Delaware limited partnership (“VSF IV”), Versant Venture Capital IV, L.P., a Delaware limited partnership (“VVC IV”), Versant Ventures II, LLC, a Delaware limited liability company (“VV II”), Versant Ventures IV, LLC, a Delaware limited liability company (“VV IV”), Brian G. Atwood (“BGA”), Samuel D. Colella (“SDC”), Ross A. Jaffe (“RAJ”), William J. Link (“WJL”), Donald B. Milder (“DBM”), Rebecca B. Robertson (“RBR”), Camille D. Samuels (“CDS”), Bradley J. Bolzon (“BJB”), Charles M. Warden (“CMW”), Barbara N. Lubash (“BNL”), Robin L. Praeger (“RLP”) and Kevin J. Wasserstein (“KJW” and together with VAF II-A, VSF II, VVC II, VSF IV, VVC IV, VV II, VV IV, BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW, BNL, KJW and RLP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)

VV II serves as the sole general partner of VSF II and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW and BNL are directors and/or members of VV II and share voting and dispositive power over the shares held by VSF II; however, they disclaim beneficial ownership of the shares held by VSF II except to the extent of their pecuniary interests therein. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009.

(3)

This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

CUSIP No. 12738T100

1

Names of Reporting Persons.
Versant Venture Capital II, L.P.

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
3,220,948 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
3,220,948 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
3,220,948 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
6.39% (3)

12

Type of Reporting Person*
PN

(1)

This Schedule 13G is filed by Versant Affiliates Fund II-A, L.P., a Delaware limited partnership (“VAF II-A”), Versant Side Fund II, L.P., a Delaware limited partnership (“VSF II”), Versant Venture Capital II, L.P., a Delaware limited partnership (“VVC II”), Versant Side Fund IV, L.P., a Delaware limited partnership (“VSF IV”), Versant Venture Capital IV, L.P., a Delaware limited partnership (“VVC IV”), Versant Ventures II, LLC, a Delaware limited liability company (“VV II”), Versant Ventures IV, LLC, a Delaware limited liability company (“VV IV”), Brian G. Atwood (“BGA”), Samuel D. Colella (“SDC”), Ross A. Jaffe (“RAJ”), William J. Link (“WJL”), Donald B. Milder (“DBM”), Rebecca B. Robertson (“RBR”), Camille D. Samuels (“CDS”), Bradley J. Bolzon (“BJB”), Charles M. Warden (“CMW”), Barbara N. Lubash (“BNL”), Robin L. Praeger (“RLP”) and Kevin J. Wasserstein (“KJW” and together with VAF II-A, VSF II, VVC II, VSF IV, VVC IV, VV II, VV IV, BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW, BNL, KJW and RLP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)

VV II serves as the sole general partner of VVC II and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW and BNL are directors and/or members of VV II and share voting and dispositive power over the shares held by VVC II; however, they disclaim beneficial ownership of the shares held by VVC II except to the extent of their pecuniary interests therein. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009.

(3)

This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

CUSIP No. 12738T100

1

Names of Reporting Persons.
Versant Side Fund IV, L.P.

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
13,056 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
13,056 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
13,056 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
0.03% (3)

12

Type of Reporting Person*
PN

(1)

This Schedule 13G is filed by Versant Affiliates Fund II-A, L.P., a Delaware limited partnership (“VAF II-A”), Versant Side Fund II, L.P., a Delaware limited partnership (“VSF II”), Versant Venture Capital II, L.P., a Delaware limited partnership (“VVC II”), Versant Side Fund IV, L.P., a Delaware limited partnership (“VSF IV”), Versant Venture Capital IV, L.P., a Delaware limited partnership (“VVC IV”), Versant Ventures II, LLC, a Delaware limited liability company (“VV II”), Versant Ventures IV, LLC, a Delaware limited liability company (“VV IV”), Brian G. Atwood (“BGA”), Samuel D. Colella (“SDC”), Ross A. Jaffe (“RAJ”), William J. Link (“WJL”), Donald B. Milder (“DBM”), Rebecca B. Robertson (“RBR”), Camille D. Samuels (“CDS”), Bradley J. Bolzon (“BJB”), Charles M. Warden (“CMW”), Barbara N. Lubash (“BNL”), Robin L. Praeger (“RLP”) and Kevin J. Wasserstein (“KJW” and together with VAF II-A, VSF II, VVC II, VSF IV, VVC IV, VV II, VV IV, BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW, BNL, KJW and RLP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)

VV IV serves as the sole general partner of VSF IV and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, RBR, CDS, BJB, CMW, RLP and KJW are directors and/or members of VV IV and share voting and dispositive power over the shares held by VSF IV; however, they disclaim beneficial ownership of the shares held by VSF IV except to the extent of their pecuniary interests therein. Includes (i) 8,704 shares held by VSF IV; and (ii) a warrant to purchase up to 4,352 shares held by VSF IV. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009.

(3)

This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

CUSIP No. 12738T100

1

Names of Reporting Persons.
Versant Venture Capital IV, L.P.

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
2,072,448 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
2,072,448 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
2,072,448 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
4.11% (3)

12

Type of Reporting Person*
PN

(1)

This Schedule 13G is filed by Versant Affiliates Fund II-A, L.P., a Delaware limited partnership (“VAF II-A”), Versant Side Fund II, L.P., a Delaware limited partnership (“VSF II”), Versant Venture Capital II, L.P., a Delaware limited partnership (“VVC II”), Versant Side Fund IV, L.P., a Delaware limited partnership (“VSF IV”), Versant Venture Capital IV, L.P., a Delaware limited partnership (“VVC IV”), Versant Ventures II, LLC, a Delaware limited liability company (“VV II”), Versant Ventures IV, LLC, a Delaware limited liability company (“VV IV”), Brian G. Atwood (“BGA”), Samuel D. Colella (“SDC”), Ross A. Jaffe (“RAJ”), William J. Link (“WJL”), Donald B. Milder (“DBM”), Rebecca B. Robertson (“RBR”), Camille D. Samuels (“CDS”), Bradley J. Bolzon (“BJB”), Charles M. Warden (“CMW”), Barbara N. Lubash (“BNL”), Robin L. Praeger (“RLP”) and Kevin J. Wasserstein (“KJW” and together with VAF II-A, VSF II, VVC II, VSF IV, VVC IV, VV II, VV IV, BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW, BNL, KJW and RLP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)

VV IV serves as the sole general partner of VVC IV and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, RBR, CDS, BJB, CMW, RLP and KJW are directors and/or members of VV IV and share voting and dispositive power over the shares held by VVC IV; however, they disclaim beneficial ownership of the shares held by VVC IV except to the extent of their pecuniary interests therein. Includes (i) 1,381,632 shares held by VVC IV; and (ii) a warrant to purchase up to 690,816 shares held by VVC IV. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009.

(3)

This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

CUSIP No. 12738T100

1

Names of Reporting Persons
Versant Ventures II, LLC

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
3,360,859 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
3,360,859 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
3,360,859 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
6.67% (3)

12

Type of Reporting Person*
OO

(1)

This Schedule 13G is filed by Versant Affiliates Fund II-A, L.P., a Delaware limited partnership (“VAF II-A”), Versant Side Fund II, L.P., a Delaware limited partnership (“VSF II”), Versant Venture Capital II, L.P., a Delaware limited partnership (“VVC II”), Versant Side Fund IV, L.P., a Delaware limited partnership (“VSF IV”), Versant Venture Capital IV, L.P., a Delaware limited partnership (“VVC IV”), Versant Ventures II, LLC, a Delaware limited liability company (“VV II”), Versant Ventures IV, LLC, a Delaware limited liability company (“VV IV”), Brian G. Atwood (“BGA”), Samuel D. Colella (“SDC”), Ross A. Jaffe (“RAJ”), William J. Link (“WJL”), Donald B. Milder (“DBM”), Rebecca B. Robertson (“RBR”), Camille D. Samuels (“CDS”), Bradley J. Bolzon (“BJB”), Charles M. Warden (“CMW”), Barbara N. Lubash (“BNL”), Robin L. Praeger (“RLP”) and Kevin J. Wasserstein (“KJW” and together with VAF II-A, VSF II, VVC II, VSF IV, VVC IV, VV II, VV IV, BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW, BNL, KJW and RLP, collectively, the “Reporting Persons”). The Reporting Persons expressly disclaim status as a “group” for purposes of this Schedule 13G.

(2)

Includes (i) 61,124 shares held by VAF II-A; (ii) 28,787 shares held by VSF II; (iii) 3,220,948 shares held by VVC II; and (vi) options to acquire 50,000 shares of Common Stock held directly by BGA for the benefit of VV II. VV II serves as the sole general partner of VAF II-A, VSF II and VVC II and owns no securities of the Issuer directly. BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW and BNL are directors and/or members of VV II and share voting and dispositive power over the shares held by VAF II-A, VSF II and VVC II; however, they disclaim beneficial ownership of the shares held by VAF II-A, VSF II and VVC II except to the extent of their pecuniary interests therein. The information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009.

(3)

This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

CUSIP No. 12738T100

1

Names of Reporting Persons
Versant Ventures IV, LLC

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x(1)

3

SEC Use Only

4

Citizenship or Place of Organization
Delaware, United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
2,085,504 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
2,085,504 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
2,085,504 shares of Common Stock (2)

10

Check box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row (9)
4.14% (3)

12

Type of Reporting Person*
OO

CUSIP No. 12738T100

1

Names of Reporting Persons
Brian G. Atwood

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row (9)
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Samuel D. Colella

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row (9)
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Ross A. Jaffe

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row (9)
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
William J. Link

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row (9)
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Donald B. Milder

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row (9)
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Rebecca B. Robertson

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Camille D. Samuels

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Bradley J. Bolzon

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Charles M. Warden

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
10.81% (3)

12

Type of Reporting Person*
IN

CUSIP No. 12738T100

1

Names of Reporting Persons
Barbara N. Lubash

2

Check the Appropriate Box if a Member of a Group*

(a)

o

(b)

x (1)

3

SEC Use Only

4

Citizenship or Place of Organization
United States of America

Number of
Shares
Beneficially
Owned by
Each
Reporting
Person With

5

Sole Voting Power
0 shares

6

Shared Voting Power
5,446,363 shares of Common Stock (2)

7

Sole Dispositive Power
0 shares

8

Shared Dispositive Power
5,446,363 shares of Common Stock (2)

9

Aggregate Amount Beneficially Owned by Each Reporting Person
5,446,363 shares of Common Stock (2)

10

Check Box if the Aggregate Amount in Row (9) Excludes Certain Shares*  o

11

Percent of Class Represented by Amount in Row 9
10.81% (3)

12

Type of Reporting Person*
IN

Item 1

(a)

Name of Issuer:
Cadence Pharmaceuticals, Inc.

Address of Issuer’s Principal Executive Offices:
12481 High Bluff Dr. Suite 200
San Diego, California

Item 2

(a)

Name of Person(s) Filing:

Versant Affiliates Fund II-A, L.P. (“VAF II-A”)

Versant Side Fund II, L.P.  (“VSF II”)

Versant Venture Capital II, L.P.  (“VVC II”)

Versant Ventures II, LLC (“VV II”)

Versant Side Fund IV, L.P. (VSF IV”)

Versant Venture Capital IV, L.P. (“VVC IV”)

Versant Ventures IV, LLC (“VV IV”)

Brian G. Atwood (“BGA”)

Samuel D. Colella (“SDC”)

Ross A. Jaffe (“RAJ”)

William J. Link (“WJL”)

Donald B. Milder (“DBM”)

Rebecca B. Robertson (“RBR”)

Camille D. Samuels (“CDS”)

Bradley J. Bolzon (“BJB”)

Charles M. Warden (“CMW”)

Barbara N. Lubash (“BNL”)

Robin L. Praeger (“RLP”)

Kevin J. Wasserstein (“KJW”)

(b)

Address of Principal Business Office:
c/o Versant Ventures

3000 Sand Hill Road

Building 4, Suite 210

Menlo Park, California  94025

(b)

Citizenship:

Entities:

VAF II-A

-

Delaware, United States of America

VSF II

-

Delaware, United States of America

VVC II

-

Delaware, United States of America

VV II

-

Delaware, United States of America

VSF IV

-

Delaware, United States of America

VVC IV

-

Delaware, United States of America

VV IV

-

Delaware, United States of America

Individuals:

BGA

-

United States of America

SDC

-

United States of America

RAJ

-

United States of America

WJL

-

United States of America

DBM

-

United States of America

RBR

-

United States of America

CDS

-

United States of America

BJB

-

United States of America

CMW

-

United States of America

BNL

-

United States of America

RLP

-

United States of America

KJW

-

United States of America

(d)

Title of Class of Securities:
Common Stock

(e)

CUSIP Number:
12738T100

Item 3

Not applicable.

Item 4

Ownership.

The following information with respect to the ownership of the Common Stock by the Reporting Persons filing this statement on Schedule 13G is provided as of February 19, 2009:

Reporting Persons

Shares Held
Directly

Sole Voting
Power

Shared
Voting
Power

Sole
Dispositive
Power

Shared
Dispositive
Power

Beneficial
Ownership

Percentage
of Class (2)

VAF II-A

61,124

0

61,124

0

61,124

61,124

0.12

%

VSF II

28,787

0

28,787

0

28,787

28,787

0.06

%

VVC II

3,220,948

0

3,220,948

0

3,220,948

3,220,948

6.39

%

VV II

0

0

3,360,859

0

3,360,859

3,360,859

6.67

%

VSF IV

13,056

0

13,056

0

13,056

13,056

0.03

%

VVC IV

2,072,448

0

2,072,448

0

2,072,448

2,072,448

4.11

%

VV IV

0

0

2,085,504

0

2,085,504

2,085,504

4.14

%

BGA

50,000

0

5,446,363

0

5,446,363

5,446,363

10.81

%

SDC

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

RAJ

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

WJL

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

DBM

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

RBR

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

CDS

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

BJB

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

CMW

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

BNL

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

RLP

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

KJW

0

0

5,446,363

0

5,446,363

5,446,363

10.81

%

(1)   VV II serves as the sole general partner of VAF II-A, VSF II and VVC II and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, DBM, RBR, CDS, BJB, CMW and BNL are directors and/or members of VV II and share voting and dispositive power over the shares held by VAF II-A, VSF II and VVC II; however, they disclaim beneficial ownership of the shares held by VAF II-A, VSF II and VVC II except to the extent of their pecuniary interests therein.  VV IV serves as the sole general partner of VSF IV and VVC IV and owns no securities of the Issuer directly.  BGA, SDC, RAJ, WJL, RBR, CDS, BJB, CMW, RLP and KJW are directors and/or members of VV II and share voting and dispositive power over the shares held by VSF IV and VVC IV; however, they disclaim beneficial ownership of the shares held by VSF IV and VVC IV except to the extent of their pecuniary interests therein. 

(2)   This percentage is calculated based upon 50,403,779 shares of Common Stock outstanding as of February 19, 2009.

Item 5

Ownership of Five Percent or Less of a Class.

If this statement is being filed to report the fact that as of the date hereof, the Reporting Persons have ceased to be the beneficial owner of more than five percent of the class of securities, check the following:   o

Item 6

Ownership of More Than Five Percent on Behalf of Another Person.

See Items 2(a) and 4.

Item 7

Identification and Classification of the Subsidiary which Acquired the Security Being Reported on by the Parent Holding Company.

Not applicable.

Item 8

Identification and Classification of Members of the Group.

Not applicable.

Item 9

Notice of Dissolution of Group.

Not applicable.

Item 10

Certification.

Not applicable.

Dated: February 25, 2009

Versant Affiliates Fund II-A, L.P.

By:

Versant Ventures II, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Side Fund II, L.P.

By:

Versant Ventures II, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Venture Capital II, L.P.

By:

Versant Ventures II, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Ventures II, LLC

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Side Fund IV, L.P.

By:

Versant Ventures IV, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Venture Capital IV, L.P.

By:

Versant Ventures IV, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Ventures IV, LLC

By:

/s/ Robin L. Praeger

Managing Member

/s/ Robin L. Praeger as attorney in fact

Brian G. Atwood

/s/ Robin L. Praeger as attorney in fact

Samuel D. Colella

/s/ Robin L. Praeger as attorney in fact

Ross A. Jaffe

/s/ Robin L. Praeger as attorney in fact

William J. Link

/s/ Robin L. Praeger as attorney in fact

Donald B. Milder

/s/ Robin L. Praeger as attorney in fact

Rebecca B. Robertson

/s/ Robin L. Praeger as attorney in fact

Camille D. Samuels

/s/ Robin L. Praeger as attorney in fact

Bradley J. Bolzon

/s/ Robin L. Praeger as attorney in fact

Charles M. Warden

/s/ Robin L. Praeger as attorney in fact

Barbara N. Lubash

/s/ Robin L. Praeger

Robin L. Praeger

/s/ Robin L. Praeger as attorney in fact

Kevin J. Wasserstein

Dated: February 25, 2009

Versant Affiliates Fund II-A, L.P.

By:

Versant Ventures II, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Side Fund II, L.P.

By:

Versant Ventures II, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Venture Capital II, L.P.

By:

Versant Ventures II, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Ventures II, LLC

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Side Fund IV, L.P.

By:

Versant Ventures IV, LLC

Its:

General Partner

By:

/s/ Robin L. Praeger

Authorized Representative

Versant Venture Capital IV, L.P.